They then investigated whether 556 women affected by “recurrent spontaneous abortion” or RSA, had mutations in the same gene. They did.
RSA is defined as a woman suffering three or more miscarriages within the first five weeks of
pregnancy. It affects about one in every 100 pregnancies.
A control group of 271 non-RSA sufferers were also included in the study.
“We found that women with FOXD1 mutations have a statistically high risk of suffering RSA,” said the team.
They also found one variant present only in the control group of women with no history of miscarriage, and speculated it may be protective.
It is not the first gene implicated in repeated miscarriage, though “functional evidence” of their involvement has been rare, the team wrote.